Long-term outcome of cardic resynchronization therapy in the dilated cardiomyopathy patients

Article Abstract: Objective：To investigate the long-term effect of cardiac resynchronization therapy （CRT） in patients with dilated cardiomyopathy.Method：Eighteen dilated cardiomyopathy patients with drug-refractory heartfailure received cardiac resynchronous pacing. Check all the patients using the two-dimensional echocardiography and Tissue Doppler imaging（TDI） before and one week after CRT. After 1 month,3 months,6 months and one year follow-up of patients with clinical symptoms,and compare the various parameters change. Result：The NYHA heart function was improved from class Ⅲ-Ⅳ to grade Ⅰ-Ⅲ. The left ventricular ejection fraction was improved from 0.264±0.067 to 0.394±0.106 after 12 months CRT treatment （P〈0.01）. The LVEDD were significantly decreased from preoperative （75.31±8.52）mm to （67.24±10.57）mm after 12 months therapy （P〈0.05）. The Ts-SD about synchronization of inter-ventricles and intra-left ventricle was improved significantly after optimize the pacemaker parameters. Conclusion：CRT can improve the synchronization of inter-ventricles and intra-left ventricle in dilated cardiomyopathy patients,reverse ventricular enlargement,improve cardiac function,its long-term effects is significant.